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Los Angeles Rams at San Francisco 49ers Preview & Picks – Rams To Win Crucial NFL Division Matchup

leigh-copson
By Leigh Copson
05 Nov 2025
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Leigh Copson 05 Nov 2025
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  • Los Angeles Rams at San Francisco 49ers picks for Sunday, November 9
  • Game is taking place at Levi's Stadium
  • Preview, predictions, stats & form
(Getty Images)
    Los Angeles Rams at San Francisco 49ers Preview & Picks
  • Los Angeles Rams at San Francisco 49ers Preview & Picks
  • Head To Head
  • Los Angeles Rams Form
  • San Francisco 49ers Form

Los Angeles Rams at San Francisco 49ers Preview & Picks

Los Angeles are tipped to cover as they avenge last month’s loss to San Francisco.

Matthew Stafford and this Rams offense is firing on all cylinders, and they have been successful in their last couple of visits to Santa Clara.

  • Los Angeles Rams are 6-2 in their 8 games
  • Los Angeles Rams have won their last 2 games at Levi’s Stadium
  • Los Angeles Rams are 5-0-0 ATS in the last 5 meetings with San Francisco
  • The Over has cashed in 5 of the previous 6 meetings

Head To Head

  • San Francisco 49ers lead the all-time series 79-71-3
  • San Francisco 49ers won 26-23 in overtime when the two teams last met on October 2

Los Angeles Rams Form

Los Angeles head out on the road riding a three-game win streak that has improved their record to 6-2.

The Rams opened the season with back-to-back victories, following up a 14-9 success against Houston with a 33-19 victory in Tennessee.

They failed to make it three-in-a-row as they lost 33-26 at Philadelphia, only to rebound with a 27-20 victory when they hosted Indianapolis.

Los Angeles were unable to back that up, losing 26-23 in overtime to San Francisco, but they have not tasted defeat since then.

The Rams bounced back with a 17-3 win in Baltimore, and followed it up by beating Jacksonville 35-7 on the road and New Orleans 34-10 at home.

San Francisco 49ers Form

San Francisco enter this matchup looking to develop some consistency, having ridden a recent rollercoaster run of form to a 6-3 record.

The 49ers opened the season with three straight wins, beating Seattle 17-13 and New Orleans 26-21 on the road, and Arizona 16-15 at home, but they have not strung together wins since then.

Their perfect start was ended by a 26-21 loss to Jacksonville, and although they rebounded with a 26-23 overtime win at the Los Angeles Rams, they failed to back it up.

San Francisco had to bounce back from a 30-19 defeat at Tampa Bay with a 20-10 win at home to Atlanta.

The 49ers then had to respond to a 26-15 defeat in Houston with a 34-24 victory when they visited the New York Giants.

Verdict

Los Angeles have built some momentum over the past few weeks and Matthew Stafford has this offense rolling.

The Rams are backed to keep it going by winning at Levi’s Stadium for the third season in a row.

Best Bet1: LA Rams -3.5 Spread @-111.11 at Stake.us - 4 Units
Best Bet2: Over 49.5 Total Points @-111.11 at Stake.us - 2 Units
LA Rams -3.5
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