2026 NFL Draft Odds – Fernando Mendoza Overwhelming Favorite To Be Number 1 Pick After Indiana Success
21 Jan 2026Read More
Los Angeles Chargers at Arizona Cardinals Preview & Picks – NFL Monday Night Football Success For Chargers
- Los Angeles Chargers at Arizona Cardinals picks for Monday, October 21
- Game is taking place at State Farm Stadium in Glendale
- Preview, predictions, stats & form
- Los Angeles Chargers at Arizona Cardinals Preview & Picks
- Head To Head
- Los Angeles Chargers Form
- Arizona Cardinals Form
Los Angeles Chargers at Arizona Cardinals Preview & Picks
Los Angeles Chargers at Arizona Cardinals Preview & Picks
Los Angeles are backed to cover as they win this road game.
The Chargers can lean on their run game and tough defense against an Arizona team that has struggled offensively in recent weeks.
- Los Angeles Chargers are 2-1-0 ATS on the road this season
- Arizona Cardinals are 1-3-0 ATS in their previous 4 games
- Arizona Cardinals have scored 14 points or less in 3 of their last 4 games
- The Under has cashed in 4 of Los Angeles Chargers’ 5 games so far
Head To Head
- Los Angeles Chargers lead the all-time series 11-4
- Los Angeles Chargers won 25-24 when the two teams last met in November 2022
Los Angeles Chargers Form
Los Angeles go out on the road for the second weekend running looking to improve their record to 4-2.
The Chargers enjoyed a solid start to the season as they won their first two games, starting with a 22-10 victory over Las Vegas.
They then went out on the road to beat Carolina 26-3, only to see their perfect start end a week later when they were beaten 20-10 in Pittsburgh.
It became back-to-back defeats when Los Angeles then returned home to lose 17-10 to division rivals, and defending Super Bowl champions, Kansas City.
The Chargers did bounce back when they returned from the bye week though, beating Denver 23-16 on the road last weekend.
Arizona Cardinals Form
Arizona enter this matchup having failed to build on their upset win over San Francisco, falling to 2-4 last weekend.
The Cardinals opened the season with a 34-28 defeat in Buffalo, but rebounded in their home opener a week later, blowing out the Los Angeles Rams, 41-10.
They failed to build on that however, as they then suffered defeats in back-to-back home games.
Arizona lost 20-13 to Detroit and 42-14 to Washington, but they avoided a third straight defeat as they pulled off a shock victory over the 49ers, 24-23.
The Cardinals’ joy was short-lived however, as they were brought back down to Earth by a 34-13 defeat at Green Bay last weekend.
Verdict
Arizona are starting to pile up losses and the offense continues to struggle.
That spells trouble against a Los Angeles defense that leads the league in points allowed per game, so we expect the Chargers to come away with a win and the cover here.
That spells trouble against a Los Angeles defense that leads the league in points allowed per game, so we expect the Chargers to come away with a win and the cover here.
55 Stake Cash no deposit & 550,000 Gold Coins & 5% Rakeback
Use promo code NEWBONUS
Sign up with the code NEWBONUS. When you verify your account get 25 Stake Cash for free PLUS 250,000 Gold Coins and 5% Rakeback! No deposit required. Login each day for the next 30 days and get an additional 30 Stake Cash AND 300,000 Gold Coins. 21+ only. T&Cs apply. Excludes WA, NY, NV, ID, KY, MI, VT, NJ, DE, WV, PA, RI & MD.
55 Stake Cash no deposit & 550,000 Gold Coins & 5% Rakeback
Use promo code NEWBONUS
Sign up with the code NEWBONUS. When you verify your account get 25 Stake Cash for free PLUS 250,000 Gold Coins and 5% Rakeback! No deposit required. Login each day for the next 30 days and get an additional 30 Stake Cash AND 300,000 Gold Coins. 21+ only. T&Cs apply. Excludes WA, NY, NV, ID, KY, MI, VT, NJ, DE, WV, PA, RI & MD.
See also
- NFL Offer - Get Double Winnings If Your Team Wins & A Selected Player Hits Their Target
- NFL 3rd Quarter Payout – Get Paid Out If Your Team Leads By 7+ Points After Three Quarters But Loses
- NFL Player Props Multi Insurance – Money Back If One Selection Lets You Down
- Baltimore Ravens at Tampa Bay Buccaneers Preview & Picks – Back Bucs In NFL Monday Night Football Matchup
- Baltimore Ravens at Tampa Bay Buccaneers - Get Double Winnings If Your Team Wins & A Selected Player Hits Target
- Los Angeles Chargers at Arizona Cardinals - Get Double Winnings If Your Team Wins & A Selected Player Hits Target
- New York Jets at Pittsburgh Steelers Preview & Picks – Under To Cash In NFL Sunday Night Football Matchup
- Kansas City Chiefs at San Francisco 49ers Preview & Picks – Chiefs To Win NFL Super Bowl Rematch
- Detroit Lions at Minnesota Vikings Preview & Picks – Unbeaten Vikings To Win Big NFL Clash
- Denver Broncos at New Orleans Saints Preview & Picks – Broncos To Beat Saints In Payton’s NFL Return To NOLA
- New England Patriots vs Jacksonville Jaguars Preview & Picks – Patriots To Cover As London NFL Underdog
Upcoming Events
09 February 2026
Alex Barrena vs Vit Kopriva Tennis
Alex Barrena vs Vit Kopriva Betting Picks & Preview - Clay Transition Poses Challenge for Kopriva in Buenos Aires
10 February 2026
Terence Atmane vs Frances Tiafoe Tennis
Frances Tiafoe vs Terence Atmane Betting Picks & Preview - Tiafoe Favored at Home in Dallas
22 February 2026
08 March 2026
Max Holloway vs Charles Oliveira 2 UFC
Max Holloway vs Charles Oliveira 2 Preview & Picks – Holloway To Retain BMF Crown At UFC 326
27 March 2026
2026 MLB World Series Betting Preview Baseball
2026 MLB World Series Odds – LA Dodgers 12/5 Favourites For 3-Peat
23 April 2026
30 June 2026
NHL 2025/26 Betting Specials Ice Hockey
NHL Daily Pick ‘Em Game – Win Cash Prizes, Trips To NHL Games & More With BET99's Free-To-Play Competition
31 December 2026
Poker EventsStarts in
Latest News
-
Latest Odds -
Back SeahawksSeattle Seahawks vs New England Patriots Preview & Picks – Seahawks To Win Super Bowl LX05 Feb 2026Read More -
Super Bowl TipsSeattle Seahawks vs New England Patriots MVP Preview & Picks – Who Will Be Named Super Bowl LX MVP?05 Feb 2026Read More -
NFL TipsSeattle Seahawks vs New England Patriots Preview & Picks – Who Will Score 1st Touchdown Of Super Bowl LX?05 Feb 2026Read More -
Player PropsSuper Bowl LX Preview & Picks – Best New England Patriots Player Prop Bets vs Seattle Seahawks05 Feb 2026Read More





