Super Bowl LXI Odds – Seattle Seahawks Favored For Back-To-Back NFL Crowns
10 Feb 2026Read More
San Francisco 49ers at Arizona Cardinals Preview & Picks – 49ers To Cover In Mexico NFL Win
- San Francisco 49ers at Arizona Cardinals picks for Monday, November 21
- Monday Night Football gets underway at 20:15 ET at Estadio Azteca in Mexico
- Preview, stats & head-to-head
- San Francisco 49ers at Arizona Cardinals Preview & Picks
- Head To Head
- San Francisco 49ers Form
- Arizona Cardinals Form
- San Francisco 49ers at Arizona Cardinals FAQs
San Francisco 49ers at Arizona Cardinals Preview & Picks
San Francisco 49ers at Arizona Cardinals Preview & Picks
San Francisco are backed to cover in Mexico.
The 49ers’ offense is a work in progress but is coming up against one of the NFL’s worst defenses.
And on the opposite side of the football, the Niners defense is getting back to their dominant best.
- San Francisco are 5-0-0 ATS in their last 5 NFC West games
- San Francisco are 9-2-0 ATS in their last 11 conference games
- Arizona are 1-6-0 ATS in their last 7 NFC West games
- The Under has cashed in 13 of San Francisco’s last 17 games
Head To Head
- San Francisco 49ers lead the all-time series 32-29
- Arizona Cardinals won 31-17 when the teams last met in November 2021
San Francisco 49ers Form
San Francisco head to Mexico having won either side of the bye week to improve to 5-4.
The 49ers stumbled out of the blocks as they lost two of their first three games of the 2022 season.
They rebounded with back-to-back wins, beating the LA Rams 24-9 and Carolina 37-15, but their momentum then stalled.
San Francisco were upset 28-14 in Atlanta before returning home for a 44-23 defeat to Kansas City.
The 49ers stopped the rot before the bye week though, dominating the Rams in a 31-14 victory.
They then backed up that victory when they returned to action last week, beating the LA Chargers 22-16 at home.
Arizona Cardinals Form
This is a massive matchup for an Arizona team who have gone 4-6 through the first 10 weeks.
The Cardinals went 2-2 through their first four games, losing at home to Kansas City and the LA Rams while beating Las Vegas and Carolina on the road.
The offense then stalled as they lost back-to-back games against Philadelphia (20-17) and Seattle (19-9).
Arizona bounced back with a 42-34 shootout win at home to New Orleans, but were unable to build on that.
The Cardinals were beaten 34-26 at Minnesota before returning home to suffer a 31-21 defeat to Seattle.
They did keep their season alive last weekend though, beating the Rams 27-17 on the road with backup QB Colt McCoy at the controls.
San Francisco 49ers at Arizona Cardinals FAQs
Where can I watch the San Francisco 49ers at Arizona Cardinals live stream?
You can watch the San Francisco 49ers at Arizona Cardinals live stream at Stake.
What is the San Francisco 49ers at Arizona Cardinals start time?
The San Francisco 49ers at Arizona Cardinals game is set to start at 20:15 ET.
Verdict
San Francisco’s defense is one of the very best in the NFL, while Arizona’s is one of the worst.
The 49ers are backed to get the stops needed to win the game and cover the spread.
The 49ers are backed to get the stops needed to win the game and cover the spread.
San Francisco -8.0
Spread
@-111.11 - 3 Units
25 SC no deposit & 250,000 GC
Use promo code NEWBONUS
Get 25 Stake Cash & 250,000 Gold Coins when you sign up with code NEWBONUS at Stake.us. USA only. Excludes certain States including NY,NV,ID, KY,WA. 18+ only. Terms and Conditions apply.
Under 43.5
Total Points
@-111.11 - 3 Units
25 SC no deposit & 250,000 GC
Use promo code NEWBONUS
Get 25 Stake Cash & 250,000 Gold Coins when you sign up with code NEWBONUS at Stake.us. USA only. Excludes certain States including NY,NV,ID, KY,WA. 18+ only. Terms and Conditions apply.
See also
- San Francisco 49ers at Arizona Cardinals – Get Double Winnings With Stake’s NFL Primetime Offer
- San Francisco 49ers at Arizona Cardinals Live Stream – How To Watch Live Online From With Stake
- Kansas City Chiefs at Los Angeles Chargers Live Stream – How To Watch Live Online With Stake
- Philadelphia Eagles at Indianapolis Colts Preview & Picks – Eagles To Bounce Back In NFL
- Dallas Cowboys at Minnesota Vikings Preview & Picks – Vikings To Cover As NFL Home Underdog
- Kansas City Chiefs at Los Angeles Chargers Preview & Picks – Chiefs To Cover In Big NFL Showdown
- Tennessee Titans at Green Bay Packers Live Stream – How To Watch Live Online With Stake
- Toronto Argonauts at Winnipeg Blue Bombers Preview & Picks – Winnipeg To Win CFL Grey Cup
- Tennessee Titans at Green Bay Packers Preview & Picks – Titans To Cover In Thursday NFL Clash
Upcoming Events
29 May 2026
Alex De Minaur vs Jakub Mensik Tennis
Alex de Minaur vs Jakub Mensik Betting Picks & Live Stream – De Minaur Holds Major Edge Over Mensik at ATP Roland Garros
Casper Ruud vs Tommy Paul Tennis
Casper Ruud vs Tommy Paul Betting Picks & Live Stream – Ruud Favoured for Straight Sets at the French Open
Charlie Edwards vs Sikho Nqothole Boxing
Charlie Edwards vs Sikho Nqothole Live Stream & Picks – How To Watch & Bet Live Online
BOS Red Sox @ CLE Guardians Baseball
Boston Red Sox at Cleveland Guardians Predictions & Picks – Guardians To Win MLB Series Opener
30 May 2026
DAL Renegades @ STL Battlehawks NFL
Dallas Renegades at St Louis Battlehawks Predictions & Picks – Battlehawks To Cover In 7th UFL Win
MON Canadiens @ CAR Hurricanes - Game 5 Ice Hockey
Montreal Canadiens at Carolina Hurricanes Predictions & Picks – Hurricanes To Wrap Up NHL Playoffs Series
PHI Phillies @ LA Dodgers Baseball
Philadelphia Phillies at Los Angeles Dodgers Predictions & Picks – Phillies To Upset Dodgers In MLB Clash
Dmitry Bivol vs Michael Eifert Boxing
Dmitry Bivol vs Michael Eifert Live Stream – How To Watch World Title Fight Live Online
Canada vs Finland Ice Hockey
Canada vs Finland Predictions & Picks – Canada To Book Spot In Ice Hockey World Championship Final
HOU Gamblers @ BHM Stallions NFL
Houston Gamblers at Birmingham Stallions Predictions & Picks – Take Gamblers & Free Points In UFL
31 May 2026
SA Spurs @ OKC Thunder - Game 7 Basketball
San Antonio Spurs at Oklahoma City Thunder Predictions & Picks – Back Thunder In Game 7 In NBA Playoffs
O'Shaquie Foster vs Raymond Ford Boxing
O'Shaquie Foster vs Raymond Ford Live Stream & Picks – How To Watch & Bet Live Online
ORL Storm @ DC Defenders NFL
Orlando Storm at DC Defenders Predictions & Picks – Storm To Wrap Up #1 Seed In UFL
LOU Kings @ CLB Aviators NFL
Louisville Kings at Columbus Aviators Predictions & Picks – Kings To Wrap Up UFL Playoff Berth
11 June 2026
2026 World Cup Futures Predictions Soccer
2026 World Cup Golden Glove: Odds, Predictions and Betting Tips
World Cup 2026 Group A Preview & Picks - Back Mexico to top the group
World Cup 2026 Group B Preview & Picks - Canadians Can Edge Swiss in Tight Section
World Cup 2026 Group C Preview & Picks - Moroccan's Tipped to Top Section
30 June 2026
NHL 2025/26 Betting Specials Ice Hockey
NHL Daily Pick ‘Em Game – Win Cash Prizes, Trips To NHL Games & More With BET99's Free-To-Play Competition
20 September 2026
Floyd Mayweather Jr vs Manny Pacquiao 2 Boxing
Floyd Mayweather Jr vs Manny Pacquiao 2 Preview & Picks – Mayweather To Repeat 2015 Victory
31 October 2026
2026 MLB Betting Specials Baseball
MLB Baseball Offer – Money Back If Your Team Leads At Start Of 9th Innings But Loses
Poker EventsStarts in
Charlie Edwards vs Sikho Nqothole
BOS Red Sox @ CLE Guardians
DAL Renegades @ STL Battlehawks
MON Canadiens @ CAR Hurricanes - Game 5
PHI Phillies @ LA Dodgers
Dmitry Bivol vs Michael Eifert
Canada vs Finland
HOU Gamblers @ BHM Stallions
SA Spurs @ OKC Thunder - Game 7
Song Yadong vs Deiveson Figueiredo
O'Shaquie Foster vs Raymond Ford
ORL Storm @ DC Defenders
Latest News
-
NFL Odds -
Back SeahawksSeattle Seahawks vs New England Patriots Preview & Picks – Seahawks To Win Super Bowl LX05 Feb 2026Read More
-
Super Bowl TipsSeattle Seahawks vs New England Patriots MVP Preview & Picks – Who Will Be Named Super Bowl LX MVP?05 Feb 2026Read More
-
NFL TipsSeattle Seahawks vs New England Patriots Preview & Picks – Who Will Score 1st Touchdown Of Super Bowl LX?05 Feb 2026Read More
-
Player PropsSuper Bowl LX Preview & Picks – Best New England Patriots Player Prop Bets vs Seattle Seahawks05 Feb 2026Read More
